We often remember this section as the Macedonian Call.  This section in Acts reminds us that there are chosen vessels that come to help in the ministry.  It may be a Timothy to help replace John Mark or it may be Paul and his ministering friends that were excited about coming to help minister wherever God might send them.  They were not deterred by the Holy Spirit blocking them from going into Asia Minor, but in God's wisdom and Providence He sent them to the Macedonians who desperately needed them,  May we be ready to answer the Lord to come in the ministry.