Jesus said that the world neither loves Him nor those that are His people.  Judas who was an evil man possessed by the devil betrayed Jesus and came into the Garden of Gethsemane with literally hundreds of combatants to take Jesus.  The world continues to despise the Lord, He is indeed "despised and rejected of men."  In the future we will see the man of sin, the anti-Christ seek to make war against the Lord along with the nations.  Sinners are spiritually foolish in thinking that they can overcome the Lord and get along without Him.